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The stock hit an over two-year high of $35.61 after the company released interim data on Saturday from the trial that tested the gene therapy, 4D-150, in patients with wet age-related macular degeneration (AMD), a leading cause of vision loss among older adults.
In a trial in combination with US pharma giant Merck's blockbuster cancer drug Keytruda, four of the 16 patients saw some clinical benefit, while all reported the disease stabilising for at least six months.
'Pantheon has an opportunity to develop a number of large, discreet oil accumulations in an established oil province adjoining export infrastructure, which we believe is unique,' said technical director Bob Rosenthal.
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'So when they would try to ground me at 17, I would say, "I pay the bills." And I cringe now when I think about that attitude,' they said. 'But when the world is putting you on a pedestal, you kind of think that you could do no wrong. As I've gotten older, I see my parents just as big kids themselves.'
Wet AMD is a long-lasting disorder that causes blurred vision or a blind spot in the central vision due to fluid or blood leaking into the macula. 4D Molecular's therapy was tested in 51 patients with severe disease that leads to thicker retinas, resulting in a high treatment burden as the patients have to depend on frequent injections such as Regeneron Pharmaceuticals' Eylea.
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'So when they would try to ground me at 17, I would say, "I pay the bills." And I cringe now when I think about that attitude,' they said. 'But when the world is putting you on a pedestal, you kind of think that you could do no wrong. As I've gotten older, I see my parents just as big kids themselves.'
'I'm not sure you can remember what you were doing at 8 years old,' Lovato said in the episode. 'I was on Barney and Friends being a kid but in many ways feeling like an adult.' (Demi pictured in 2004's Camp Rock)
The Camp Rock alum, who identifies as pansexual, said that they don't want to be seen as an 'expert or spokesperson,' and has 'opened up another level of vulnerability' by sharing the news with their fans.
An estimated 19.8 million Americans aged 40 and older were living with age-related macular degeneration, according to data from the Centers for Disease Control and Prevention, of which 1.49 million were at a risk of losing their vision.
'I noticed that when I came into the spotlight at a young age, and then was the breadwinner, there wasn't a manual for my parents to read and it say, "Here's what to do to raise a child star,"' said Lovato on the podcast. 'They didn't get that.'
Adverum and Regenxbio are also developing gene therapies for the disease, but BMO Capital Markets analyst Kostas Biliouris said Adverum's therapy has safety concerns, while the administration of Regenxbio's therapy is not convenient.
In the context of a severe patient population whose retinal thickness is 1.6 times above normal despite 10 prior injections over the last year, RBC Capital Markets analyst Lisa Walter said "you could not ask for a much better result."
'I noticed that when I came into the spotlight at a young age, and then was the breadwinner, there wasn't a manual for my parents to read and it say, "Here's what to do to raise a child star,"' said Lovato on the podcast. 'They didn't get that.'
'I didn't get the 30-day Malibu treatment center,' Barrymore recalled. 'It was nothing like I was in. I was in hardcore Van Nuys Psychiatric. You acted out, you got thrown into the stretcher restraints or the solitary confinement room.'
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